Rheumatoid Arthritis B And T Cells

B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis.

Rheumatoid arthritis b and t cells. The role of t cells and their actions in rheumatoid arthritis ra has been the focus of a great deal of research for some time 1 mainly as a result of many observations in human patients and experimental animal models the association of human leukocyte antigen hla dr a mhc class ii cell surface receptor in ra provides the strongest evidence that cd4 t cells are involved in the. Collagen induced arthritis and the tnf transgenic mice. Here we show that b cells are enriched in the subchondral and endosteal bone marrow bm areas adjacent to osteocalcin obs in two murine ra models. Müller ladner u ospelt c gay s distler o pap t.

They are the source of the rheumatoid factors and anticitrullinated protein antibodies which contribute to immune complex formation and complement activation in the joints. B cells also mediate t cell activation through expression of costimulatory molecules. B cells are also very efficient antigen presenting cells and can contribute to t cell activation through expression of costimulatory. Cells of the synovium in rheumatoid arthritis.

Immune responses potentially orchestrated by b cells in rheumatoid arthritis. As such ra is often considered the prototype disease for defining both the molecular and pathological basis of immune mediated chronic inflammatory disease and for validating targeted therapies. In ra the main function of t cells is to activate macrophages and fibroblasts and transform them into tissue destructive cells. To define the cell populations that drive joint inflammation in rheumatoid arthritis ra we applied single cell rna sequencing scrna seq mass cytometry bulk rna sequencing rna seq and flow cytometry to t cells b cells monocytes and fibroblasts from 51 samples of synovial tissue from patients with ra or osteoarthritis oa.

The effects of b cells extend beyond their roles in forming plasma cells including cytokine production direct cellular interactions and they themselves serve as antigen presenting cells to t lymphocytes. Pubmed central article pubmed google scholar. B cells and plasma cells can be found in rheumatoid synovium sometimes as lymphoid aggregates in the subsynovium. These structures likely play a key role in t cell b cell.

Rheumatoid arthritis ra is one of the most common chronic inflammatory syndromes. The multiple roles of b cells in rheumatoid arthritis. Similar to t and b cells activated macrophages produce a variety of cytokines and chemokines to support the inflammation in the. B t cell interactions result in the activation and differentiation of plasma cells responsible for the production of autoantibodies in turn activated b cells provide help to t cells and induce differentiation of effector t cells that produce.